[期刊论文]

出版年：2007

Pudina extract (Mentha spicata Linn.) used as flavoring in culinary preparation throughout the plains of India was examined for its DNA damage protecting activity and antioxidant potential. n-Butanol soluble fraction (PE) derived from methanol extract of Mentha spicata Linn. at 10μg/ml exhibited significant protecting activity against DNA strand scission by OH on pBluescript II SK(? DNA. IC₅₀ concentration of PE to scavenge DPPH , ABTS ⁺ and superoxide radical was 7.47, 4.05 and 57.80μg/ml, respectively. Inhibition of lipid peroxidation induced with 25mM FeSO₄ on rat liver homogenate as lipid source was noted at 500μg/ml of PE with Antioxidant Index of 63.43%. Total polyphenol content of one-milligram pudina extract was equivalent to 500μg of gallic acid. Therefore, this potential bioactivity of pudina extract was associated with its high polyphenolic content.

Pudina extract;DNA damage;DPPH ;ABTS ⁺ ;Superoxide radical;Lipid peroxidation inhibition;Polyphenol;Antioxidant activity