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Enzyme inhibitors play a significant role in the drug discovery process. For
instance, acetylcholinesterase (AChE) inhibitors have applications in curing
Alzheimer’s disease (AD), senile dementia, ataxia, myasthenia gravis, and
Parkinson’s disease. Glutathione S -transferase (GST) inhibitors
have applications as adjuvants to overcome anticancer and antiparasitic drug
resistance problems. Compounds inhibiting the activity of α-glucosidase are used
to treat type 2 diabetes mellitus and obesity problems. This article describes
the identification of natural products exhibiting AChE, GST, and α-glucosidase
inhibitory activities from medicinally important plants. Additionally,
structure–activity relationship (SAR) studies of these newly discovered enzyme
inhibitors are also discussed.
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