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[期刊论文][research article]
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Mixed ligand Cu(II) complexes containing o-vanillin-l-tryptophan Schiff base and heterocyclic nitrogen bases: synthesis, structural characterization, and biological properties
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作 者：
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L. Subha;C. Balakrishnan;S. Thalamuthu;M.A. Neelakantan;
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出版年：2015
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页 码：1021 - 1039
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出版社：Taylor And Francis
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摘 要：
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[Cu(L)] (1) and mixed ligand copper(II) complexes [Cu(L)(A)] (2 and 3), where L is the Schiff base derived from o-vanillin and l-tryptophan and A is pyridine (2) and imidazole (3), were synthesized and characterized using conventional and spectral techniques. 2 was structurally characterized using single crystal X-ray crystallography showing that Cu(II) is coordinated through N2O2 donors in a square plane. The EPR spectra of the complexes in frozen solution support a square-based structure. Electrochemical behavior of the complexes has been studied by cyclic voltammetry. The DNA-binding properties of L and 1–3 with calf thymus DNA were investigated by spectral and kinetic methods. For all the complexes, the maximum value of binding constant (0.38 × 106) was achieved with 3 by spectroscopic titration. The ability of compounds to break pUC19 DNA was checked by gel electrophoresis. The ligand and copper complexes exert cytotoxicity against MCF-7 cell line.
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关键字：
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Copper(II) complex;Amino acid Schiff base;Crystal structure;Spectroscopy;DNA binding and cleavage
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所属期刊
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ISSN: 0095-8972
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来自：Taylor And Francis
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