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[期刊论文][Full Research Paper]
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Cross metathesis-mediated synthesis of hydroxamic acid derivatives
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作 者:
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Shital Kumar Chattopadhyay;Subhankar Ghosh;Suman Sil;
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出版年:2018
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页 码:3070 - 3075
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出版社:Beilstein - Institut zur Foerderung der Chemischen Wissenschaften
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摘 要:
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An alternative synthesis of α,ß-unsaturated hydroxamates via cross metathesis between a class-I olefin and N -benzyloxyacrylamide is reported. The reaction proceeds better in the presence of Grubbs’ second generation catalyst within short time and in good yields (57–85%) with a range of substrates. Subsequent hydrogenation of each of the CM products delivers the title compounds in moderate to very good yield (70–89%). An important demonstration of the protocol is the preparation of the unusual amino acid component of the bioactive cyclic peptide Chap-31.
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关键字:
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catalysis;cross metathesis;hydroxamates;α-amino acid
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全文
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