[期刊论文][Full Research Paper]


Cross metathesis-mediated synthesis of hydroxamic acid derivatives

作   者:
Shital Kumar Chattopadhyay;Subhankar Ghosh;Suman Sil;

出版年:2018

页     码:3070 - 3075
出版社:Beilstein - Institut zur Foerderung der Chemischen Wissenschaften


摘   要:

An alternative synthesis of α,ß-unsaturated hydroxamates via cross metathesis between a class-I olefin and N -benzyloxyacrylamide is reported. The reaction proceeds better in the presence of Grubbs’ second generation catalyst within short time and in good yields (57–85%) with a range of substrates. Subsequent hydrogenation of each of the CM products delivers the title compounds in moderate to very good yield (70–89%). An important demonstration of the protocol is the preparation of the unusual amino acid component of the bioactive cyclic peptide Chap-31.



关键字:

catalysis;cross metathesis;hydroxamates;α-amino acid


全文
所属期刊
Beilstein Journal of Organic Chemistry
ISSN:
来自:Beilstein - Institut zur Foerderung der Chemischen Wissenschaften