Background: Pre-eclampsia along with its consequences is one of the primary driver of maternal morbidity and horribleness. Despite the availability of magnificent literature, the onset of pre-eclampsia has yet not been fully understood. Objectives: To compare the serum calcium level among pre-eclampsia and the normal women during pregnancy. Patients and Methods: Study Design: Hospital based case control study. Setting: Gynecology Department of Jinnah Hospital Lahore. Period: 1 st July 2014 to 31 December 2014. The study groups consist of the 30 pre-eclamptic subjects and women with normal pregnancies. The serum calcium level of the subjects under this study was determined using standard colorimetric analyzer. Results: The results of our study determined that serum calcium level among the pre-eclamptic and the normotensive pregnant women was statistically significantly lower as compared to the normal pregnant women. Conclusion: The findings of current work are statistically significant to establish that concentration of serum calcium among pre-eclamptic subjects is lower than in the normotensive women during pregnancy.