[期刊论文]


Discriminating protein structure classes by incorporating Pseudo Average Chemical Shift to Chou's general PseAAC and Support Vector Machine

作   者:
Maqsood Hayat;Nadeem Iqbal;

出版年:2014

页     码:184 - 192
出版社:Elsevier BV


摘   要:

Proteins control all biological functions in living species. Protein structure is comprised of four major classes including all-α class, all-β class, α+β, and α/β. Each class performs different function according to their nature. Owing to the large exploration of protein sequences in the databanks, the identification of protein structure classes is difficult through conventional methods with respect to cost and time. Looking at the importance of protein structure classes, it is thus highly desirable to develop a computational model for discriminating protein structure classes with high accuracy. For this purpose, we propose a silco method by incorporating Pseudo Average Chemical Shift and Support Vector Machine. Two feature extraction schemes namely Pseudo Amino Acid Composition and Pseudo Average Chemical Shift are used to explore valuable information from protein sequences. The performance of the proposed model is assessed using four benchmark datasets 25PDB, 1189, 640 and 399 employing jackknife test. The success rates of the proposed model are 84.2%, 85.0%, 86.4%, and 89.2%, respectively on the four datasets. The empirical results reveal that the performance of our proposed model compared to existing models is promising in the literature so far and might be useful for future research. Copyright © 2014 Elsevier Ireland Ltd. All rights reserved.



关键字:

PseAA composition ; Pseudo Average Chemical Shift ; SVM ; Protein structure classes


所属期刊
Computer Methods and Programs in Biomedicine
ISSN: 0169-2607
来自:Elsevier BV