[期刊论文][Journal Article;Review]

出版年：2010

Bone, as well as liver and lung, is one of the most preferential metastatic target sites for cancers including breast, prostate, and lung cancers and the consequences are always devastating. Like other metastasis, breast cancer bone metastasis consists of several steps from the escape of primary site to the colonization in target site. This review focuses on several key steps including: 1. Invasion and escape from primary tumor site. 2. Target migration toward bone. 3. Specific adhesion and arrest in bone. 4. Establishment of metastasis in bone. The factors involved in this process will provide good targets for therapy. Copyright (c) 2009 Elsevier Ireland Ltd. All rights reserved.

FGFs; fibroblast growth factors ; PDGFs; platelet-derived growth factors ; BMPs; bone morphogenetic proteins ; E-cadherin; epithelial cell adhesion molecule ; MAPK-ERK; microtubule-associated protein kinase-extracellular signal-regulated kinases ; MMPs; matrix metalloproteinases ; ECM; extracellular matrix ; TIMPs; tissue inhibitors of matrix metalloproteinase ; MT1-MMP; membrane-type 1 matrix metalloproteinase ; MMPIs; MMP inhibitors ; TGF^2; transforming growth factor ^2 ; IGF; insulin-like growth factors I and II ; RGD; ArgGlyAsp ; IGFIR; IGF type I receptor ; IRS-1; insulin receptor substrate 1 ; PI-3 kinase; phosphoinositide 3-kinases ; uPA; urokinase plasminogen activator ; MAPK; mitogen-activated protein kinases ; CXCL12; CXC ligand 12 ; CXCR4; CXC receptor ; Akt; protein kinase B ; NF-@?B; Nuclear factor @?B ; PO"4; phosphate ; NPT; sodium-dependent phosphate transporters ; CasR; calcium-sensing receptors ; SCID; sever combined immune deficiency ; SDF-1; stromal derived factor-1 ; PTH-rP; parathyroid hormone related protein ; RANK; receptor activator of nuclear factor @?B ; RANKL; receptor activator of nuclear factor @?B ligand ; Bone metastasis ; PTH-rP ; IGF ; TGF ; Vicious cycle