Abstract In this paper, we introduce two autoradiography imaging systems from Packard Instrument Company, that provide unmatched speed, accuracy, sensitivity, and resolving power for radioisotopic imaging in biomedical research. The first system is a direct nuclear imaging system, which provides fast and accurate nuclear counting without intermediate steps. Data are displayed in real time so that counting, imaging and data analysis can be done all at the same time. The second system is a new storage phosphor system that was designed with a unique optical assembly which provides high resolution imaging. With various types of phosphor screens, one can optimize the performance of this storage phosphor system with any radiolabel and any appropriate sample size. With these two systems, quantitative radioisotopic imaging becomes not only faster and easier, but also more consistent and accurate, providing researchers with a higher standard in molecular biology imaging.