[期刊论文][article]


Naturally occurring enzyme inhibitors and their pharmaceutical applications

作   者:
Athar Ata;Samina Naz;Evan M. Elias;

出版年:2011

页     码:1741 - 1749
出版社:De Gruyter


摘   要:

Enzyme inhibitors play a significant role in the drug discovery process. For instance, acetylcholinesterase (AChE) inhibitors have applications in curing Alzheimer’s disease (AD), senile dementia, ataxia, myasthenia gravis, and Parkinson’s disease. Glutathione S -transferase (GST) inhibitors have applications as adjuvants to overcome anticancer and antiparasitic drug resistance problems. Compounds inhibiting the activity of α-glucosidase are used to treat type 2 diabetes mellitus and obesity problems. This article describes the identification of natural products exhibiting AChE, GST, and α-glucosidase inhibitory activities from medicinally important plants. Additionally, structure–activity relationship (SAR) studies of these newly discovered enzyme inhibitors are also discussed.



关键字:

acetylcholinesterase;α-glucosidase;antibacterial activity;Artocarpus nobilis; Barleria prionitis;B. natalensis; Buxushyrcana;glutathione S-transferase.


所属期刊
Pure and Applied Chemistry
ISSN: 0033-4545
来自:De Gruyter