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Abstract Introduction: We aimed to assess the uptake of the pilot multiday take-home dose methadone program during COVID-19 by the patients and document the experience with this novel approach to Methadone Maintenance Treatment （MMT） in Vietnam through this operational research. Materials and methods: A total of 10 clinics were identified randomly using the PPS method. A total of 502 patients were selected from the clinics using a simple randomization technique. The information was collected from the administrative and treatment records and direct face-to-face interview with the patients. Results: None of the clinics reported an incidence of overdose. A large majority of the patients reported that take home methadone program as being convenient （79.6%） and agreed that they shall like to join the multiday take-home dose in future （98.7%）. Conclusions: The findings of the current study suggested that the multiday take-home methadone program was feasible and well accepted by the patients in Ho Chi Minh City. It helped ensure continuity of care to patients on MMT during the COVID-19 pandemic.
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