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Abstract Two oxoperoxovanadium（V） complexes, [VO（O2）（BHA）（bp）] （ 1 ） and [VO（O2）（BHA）（phen）] （ 2 ）, containing benzhydroxamic acid （BHA）, 1,10-phenanthroline （phen） and 2,2-bipyridyl （bp） ligands are synthesized and the structure of the complexes have been confirmed by single-crystal X-ray crystallography. The DNA-binding studies of the complexes as assessed by UV absorption and fluorescence methods using CT-DNA suggest the possible mode of interaction as groove binding. The gel electrophoresis further supports the feasible interactions of complexes with DNA. The binding constants （Kb） and Stern-Volmer （KSV） constants of 1 and 2 are 5.4（±0.21）×104 M?1 and 5.1（±0.10）×104 M?1 and 5.668（±0.08）×105 M?1 and 1.468（±0.07）×105 M?1, respectively.
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