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Abstract Flavonolignans, for example, silymarin and silybin, have interesting biological activities. For the first time, three new flavonolignans named oenanthenoid A-C （ 1 – 3 ） and nine known flavonolignan derivatives （ 4 – 12 ） were isolated from Oenanthe javanica . Comprehensive spectroscopic data analysis and references were used to identify all of the compounds. The anti inflammatory activities of these isolates （ 1 – 12 ） on RAW264.7 macrophage cells were investigated. Three new compounds （ 1 – 3 ） demonstrated anti inflammatory activity with IC50 values ranging from 6.5?±?0.6 to 14.7?±?1.6?μM. Furthermore, two compounds （ 11 and 12 ） demonstrated moderate anti inflammatory activity, with IC50 values ranging from 24.1?±?1.2 to 62.5?±?1.9?μM.
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