Abstract Flavonolignans, for example, silymarin and silybin, have interesting biological activities. For the first time, three new flavonolignans named oenanthenoid A-C ( 1 – 3 ) and nine known flavonolignan derivatives ( 4 – 12 ) were isolated from Oenanthe javanica . Comprehensive spectroscopic data analysis and references were used to identify all of the compounds. The anti inflammatory activities of these isolates ( 1 – 12 ) on RAW264.7 macrophage cells were investigated. Three new compounds ( 1 – 3 ) demonstrated anti inflammatory activity with IC50 values ranging from 6.5?±?0.6 to 14.7?±?1.6?μM. Furthermore, two compounds ( 11 and 12 ) demonstrated moderate anti inflammatory activity, with IC50 values ranging from 24.1?±?1.2 to 62.5?±?1.9?μM.
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