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In this paper, we study effect of channel block (CB) on multiple coherence resonance (MCR) in adaptive scale-free Hodgkin–Huxley neuronal networks with spike-timing-dependent plasticity (STDP). It is found that potassium CB suppresses MCR, but sodium CB can enhance MCR, and there is optimal sodium CB level by which MCR becomes most pronounced. In addition, STDP has a significant influence on the effect of CB on MCR. As adjusting rate A p of STDP increases, for potassium CB there is proper A p by which MCR is most pronounced; however, for sodium CB MCR is reduced. These findings could provide a new insight into effect of CB on information processing in neural systems.
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