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[期刊论文]
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Tuning a P450 Enzyme for Methane Oxidation†
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作 者：
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Dr. Felipe E. Zilly;Dr. Juan P. Acevedo;Dr. Wojciech Augustyniak;Alfred Deege;Ulrich W. H<IMG alt="[a WITH DIAERESIS]" src="http://onlinelibrarystatic.wiley.com/undisplayable_characters/0000e4.gif">usig;Prof. Manfred T. Reetz;
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出版年：2013
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页 码：2720 - 2724
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出版社：John Wiley & Sons, Ltd.
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摘 要：
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A new spin: The addition of chemically inert perfluoro carboxylic acids (green; see picture) to P450 enzymes results in dramatic activation of their catalytic activity as a result of the conversion of the Fe/heme from a low-spin to a high-spin state, and the reduction of the binding-pocket size. Together these effects allow otherwise inert substrates such as propane and even methane to be oxidized.
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关键字：
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alkanes;C![[BOND]](http://onlinelibrarystatic.wiley.com/undisplayable_characters/00f8ff.gif) H activation;host–guest systems;methane oxidation;P450 enzymes
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所属期刊
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ISSN: 1433-7851
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来自：John Wiley & Sons, Ltd.
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