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BACKGROUND: Cataract formation is mostly considered to be a multi-factorial disease and oxidative stress might be one of the leading cause. Tissue oxidative stress may be due to increased oxidant production and/or a decreased antioxidant capacity in cells characterized by the release of free radicals, resulting in cellular degeneration. The imbalance between the rate of free radical production and the antioxidant defense causes cellular damage resulting in lipid peroxidation. Oxidative stress is involved in many ocular diseases. The effect of Reactive oxygen species as measured by lipid peroxidation product, Malondialdehyde and the efficiency of antioxidant capacity represented by Superoxide dismutase and Zinc and their role in pathogenesis of cataract. MATERIALS AND METHODS: A total number of 100 newly diagnosed cataract cases and 60 Age matched controls were included in the study. Biochemical markers like Serum malondialdehyde, Superoxide dismutase and serum zinc were estimated in the bloodsamples of all cases and controls. RESULT: Increased levels of Malondialdehyde and decreased levels of Superoxide dismutase and Zinc support that oxidative stress may be implicated in the development of senile cataract. SUMMARY AND CONCLUSIONS: In the present study Serum malondialdehyde is the best marker to identify oxidative stress followed by Superoxide dismutase. The diagnostic accuracy is represented by area under curve, which is highest for Malondialdehyde followed by Superoxide dismutase and Zinc
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