|
A novel, copper(II)-catalyzed cascade Csp2-P/C-C bond formation of o-haloaryl isothiocyanates with organophosphorus esters has been developed under mild conditions. A series of benzo[d]thiazol-2-ylphosphonates were synthesized in moderate to good yields. Different from the traditional method of obtaining those scaffolds with radical reactions, the method proposed allows to access them in ionic reaction and has the advantages of easy access to raw materials, simple operation. Finally, we carried out a gram-scale experiment to further demonstrate the scalbility of this strategy in the efficient synthesis of benzo[d]thiazol-2-ylphosphonates
|
