[期刊论文]


The Anti-Inflammatory Effect of a Probiotic Cocktail in Human Feces Induced-Mouse Model

作   者:
Afsaneh Salimi;Amin Sepehr;Niloofar Hejazifar;Maliheh Talebi;Mahdi Rohani;Mohammad Reza Pourshafie;

出版年:暂无

页    码:暂无
出版社:Springer Nature


摘   要:

Inflammatory bowel disease (IBD) is a chronic inflammatory disease of the gastrointestinal tract due to altered interaction between the immune system and the gut microbiota. The aim of this study was to investigate the role of a probiotic cocktail in modulating immune dysregulation induced in mice. Mice were divided into 5 groups (n = 5/group), and inflammation was induced in two separate groups by fecal microbiota transplantation (FMT) from the stool of human with IBD and dextran sulfate sodium (DSS). In the other two groups, the cocktail of Lactobacillus spp. and Bifidobacterium spp. (108CFU/kg/day) was administered daily for a total of 28days in addition to inducing inflammation. A group as a contcxsrol group received only water and food. The alteration of the selected genera of gut microbiota and the expression of some genes involved in the regulation of the inflammatory response were studied in the probiotic-treated and untreated groups by quantitative real-time PCR. The selected genera of gut microbiota of the FMT and DSS groups showed similar patterns on day 28 after each treatment. In the probiotic-treated groups, the population of the selected genera of gut microbiota normalized and the abundance of Firmicutes and Actinobacteria increased compared to the DSS and FMT groups. The expression of genes related to immune response and tight junctions was positively affected by the probiotic. Changes in the gut microbiota could influence the inflammatory status in the gut, and probiotics as a preventive or complementary treatment could improve the well-being of patients with inflammatory bowel disease symptoms.

© 2023. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.



关键字:

and tight junction proteins;fecal microbiota transplantation;gut microbiota;inflammatory bowel disease;inflammatory response;probiotic cocktail


所属期刊
Inflammation
ISSN: 0360-3997
来自:Springer Nature