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In this work, the development of a wearable electrochemical sensor for the direct measurement of uric acid in human sweat is reported. The preparation of Ni and reduced graphene oxide composites with stable electrocatalytic responses, as well as their structural characterization, was carried out. The electrochemical properties of the Ni/RGO/CCF modified electrode of conductive cotton fabric were investigated for the purpose of uric acid determination using differential pulse voltammetry. On a scale ranging from 10 μM to 60 μM, the electrode signals (Ni/RGO/CCF) were found to be linearly related to the uric acid concentration. It was possible to attain a low limit of detection (5.083 μM) with good reproducibility. Finally, an interference investigation and real-time sample analysis of the modified electrode demonstrate that it has a great potential for use as disposable sensors in biological systems.
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