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The association between processed meat intake and bladder cancer risk has been evaluated by several observational studies with inconsistent results.
In a cohort of 101,721 subjects in the Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial, we analyzed the association of processed meat intake with bladder cancer risk.
After a median of 12.5 years of follow-up, 776 new cases of bladder cancer were identified. Intake of processed red meat was significantly associated with the incidence of bladder cancer after multivariate adjustment (Highest vs. lowest quintile: HR 1.47, 95% CI 1.12-1.93; P for trend = 0.008). By contrast, there was only a suggestive but not significant association between intake of total processed meat and bladder cancer risk after multivariable adjustment (Highest vs. lowest quintile: HR 1.16, 95% CI: 0.89-1.50; P for trend = 0.073).
This large prospective study suggests that intake of processed red meat is associated with a higher risk of bladder cancer.
Bladder cancer risk is increased with cumulative intake of processed red meat.
Copyright ©2019, American Association for Cancer Research.
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