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A new series of phenolic esters 2 ( a – j ) and amides 3 ( a – c ) of 2-(1-benzofuran-2-yl) quinoline-4-carboxylic acid were synthesized by the reaction of 2-(1-benzofuran-2-yl)-quinoline-4-carboxylic acid ( 1 ) with various substituted phenols and secondary amines using ethyl-( N ′, N ′-dimethylamino)propyl carbodiimide hydrochloride (EDC.HCl) as a coupling agent. The newly synthesized compounds were evaluated for in vitro antioxidant and antibacterial activity. Among all tested compounds 2a , 2c , 2e , and 2h showed good chelating ability with Fe+2 ions, whereas compounds 2g and 2j exhibited good scavenging activity with DPPH free radicals. Concerning antibacterial activities compounds 2a , 2b , 2c , and 2h were found to be equipotent to ampicillin against Enterococcus sp and Staphylococcus aureus , while compound 2e is found to be as potent as ampicillin against Pantoea Dispersa and Ochrobactrum sp. amide derivatives 3 ( a – c ) were found to be less potent when compared to standard.
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