Hexammine ruthenium(III) chloride, (Ru[NH3]6)Cl3, a potent novel compound, eliminated 100% of pBR322 and pBR329 plasmids from Escherichia coli , rendering the bacteria vulnerable to the antibiotic-resistance markers carried on these plasmids. However, the curing activity of hexammine ruthenium(III) chloride was pH dependent.
|