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The objective of this paper is to investigate the influence of the coupling of torsional and soft-first-story effects to the seismic behavior of reinforced concrete frame buildings. For this purpose, several structural models, considering the variation of structural stiffness in the plane of each story and over the height of the structure, were generated. The effect of masonry infills non-uniformly distributed in plan was also examined. Each model was subjected to six strong ground motions acting, simultaneously, in two orthogonal directions. Inelastic dynamic analysis was performed. Results from 708 cases were exanimated, and useful conclusions concerning the inelastic response are derived.
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