[期刊论文][Article]


Ca 2+ -activated Cl - channels: a newly emerging anion transport family

作   者:
Catherine Fuller;Hong-Long Ji;Albert Tousson;Randolph Elble;Bendicht Pauli;Dale Benos;

出版年:2001

页     码:S107 - S110
出版社:Springer Nature


摘   要:

A new family of chloride transport proteins has recently emerged. These proteins have extensive homology to a protein previously isolated from bovine tracheal epithelium that acts as a Ca(2+)-sensitive Cl(-) channel (CaCC) when heterologously expressed or when reconstituted into planar lipid bilayers. Several new members of this family have been identified in human, murine, and bovine epithelia, in addition to some other tissues, and are associated with Ca(2+)-sensitive conductive chloride transport when heterologously expressed in Xenopus oocytes or HEK 293 cells. The expressed current is also sensitive to inhibitors such as DIDS and niflumic acid. In addition, at least one family member acts as an endothelial cell adhesion molecule. This emerging family may underlie the Ca(2+)-mediated Cl(-) conductance responsible for rescue of the cystic fibrosis (CF) knockout mouse from significant airway disease.



关键字:

Calcium; Cell adhesion; Channels; CLCA family; Cystic fibrosis; Epithelia; Electrophysiology; Inositol polyphosphates


所属期刊
Pflügers Archiv - European Journal of Physiology
ISSN: 0031-6768
来自:Springer Nature