[期刊论文]


Mutagenesis of the thiostrepton precursor peptide at Thr7 impacts both biosynthesis and function

作   者:
Chaoxuan Li;Feifei Zhang;Wendy L. Kelly;

出版年:2012

页     码:558 - 560
出版社:Royal Society of Chemistry (RSC)


摘   要:

The seventh residue of thiostrepton is predicted to be critical for antibacterial activity. Substitution of Thr7 in the thiostrepton precursor peptide disrupts both biological activity and the successful biosynthesis of analogs.



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所属期刊
Chemical Communications
ISSN: 1359-7345
来自:Royal Society of Chemistry (RSC)